The "Synthesis of p-methoxyacetophenone from anisole" using a zeolite catalyst is an easily conducted experiment, which gives the desired product in medium yield and with good selectivity. The purity of the product is very high.

The mass efficiency is high to very high if compared with other NOP experiments (depending on the batch size), thus we evaluate it as good . The energy efficiency of the zeolite catalyzed experiment is substantially better than that of the alternative with scandium triflate catalyst, because an energy-consuming recycling of the catalyst is not neccessary.

(Eco)toxicological data for the educt anisole and the product p-methoxyacetophenone are incomplete. Experimental research on chronic toxicity is missing for these substances, but theoretical prediction methods do not suggest possible chronic toxicity . The second educt acetic anhydride is a dangerous substance because of it's corrosive properties, but appropriate safety precautions can minimize this hazard effectively. The solvent ethanol is of low acute toxicity and is chronically toxic only with oral ingestion of larger amounts. The zeolite catalyst zeolite H-BEA 25 also does not pose a risk to human health . The solvent dichloromethane used in the analytical determinations is a suspected carcinogen, but an exposition to the small amounts used in chromatography can easily be prevented.

All organic substances used in the experiment are biologically easily degradable and mineralizable. Also they exhibit only low or medium toxicity to aquatic organisms .

Summed up we evaluate this experiment with a very good economic efficiency and low (eco)toxicological risks as well as a low environmental persistence of the substances with the "green light".