| Overview |
| Instructions |
| Operating scheme |
| Substances |
| Equipment |
| Evaluation |
| Analytics |
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; Side reactions |
Synthesis of p-methoxyacetophenone from anisole |
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Synthesis instructions as PDF file for printing |
Reaction
1.08 g (1.09 mL, 10.0 mmol)
anisole,
1.53 g (1.42 mL, 15.0 mmol)
acetic anhydride
and 0.288 g
Zeolite H-BEA 25
are placed into a 10 ml round bottom flask containing a magnetic stir bar and
fitted with a reflux condenser. The reaction mixture is heated with stirring
for 6 hours to 150 °C.
Work upThe catalyst is filtered off using a Buechner funnel (Ø = 2.0 cm) and washed with 15 ml ethanol. The filtrate is concentrated on a rotary evaporator.Crude product yield: 1.35 g; The crude product is distilled in a kugelrohr distillation apparatus at 25 hPa (oil bath temperature up to 165 °C). Yield: 1.11 g; melting point 35.6-37.5 °C; white solid Duration of the experiment6 hours for the reaction, 1.5 hours for the distillationWhere can I stop the experiment?After heating under reflux and after concentrating with the rotary evaporator. |
Suggestions for waste disposal |
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