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| Identity |
| 3D Structure |
| Physicochemical data |
| Environmental fate |
| Mammal toxicology |
| Ecotoxicology |
| Metabolism |
| Safety classifications |
| Evaluation |
2,4-Dinitrotoluene [121-14-2] |
| The pattern of metabolism of 2,4-dinitrotoluene (1) is very complex. 2,4-Dinitrotoluene (1) may be reduced in mammals by gut bacteria at any of the two nitro groups to give two aromatic amines (2) and (3). These can be further reduced to 2,4-diaminotoluene (4). 4-Amino-2-nitrotoluene (2) and the carcinogenic 2,4-diaminotoluene (4) are acetylated at their amino groups in the liver and can be excreted in urine. Another - oxidative - metabolic pathway is catalyzed by cytochrome P450 in the liver and yields 2,4-dinitrobenzyl alcohol (5), which may be further oxidized via the correspondent aldehyde to 2,4-dinitrobenzoic acid (6) or conjugated with glucuronic acid to the glucuronide (7) and excreted. All compounds reduced by the gut flora may be also oxidized by the liver at the methyl group to give the respective alcohols, aldehydes and carboxylic acids. |
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