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| Identity |
| 3D Structure |
| Physicochemical data |
| Metabolism |
| Safety classifications |
Phenol [108-95-2] |
| Phenol (1) may be directly conjugated with sulfate (5) or glucuronic acid (6) by the liver and excreted. Also it may be hydroxylated by cytochrome P450 to yield hydroquinone (2) and catechol (3). Both hydroxylation products are either excreted as sulfates and glucuronides (8+9) respectively (12+13) or undergo another oxidation to the correspondent quinones (7) and (10). An additional hydroxylation to 1,2,4-trihydroxybenzene (4), which also can form a quinone (14) has been observed. All quinones are capable of binding directly to biological macromolecules. Detoxification and excretion of the quinone metabolites is possible by rection with glutathion, with mercapturic acids as ultimate metabolites, e.g. (11). |
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