 |
| Identity |
| 3D Structure |
| Physicochemical data |
| Environmental fate |
| Mammal toxicology |
| Ecotoxicology |
| Metabolism |
| Safety classifications |
| Evaluation |
2,6-Dinitrotoluene [606-20-2] |
| 2,6-Dinitrotoluene (1) may be reduced at one of the two nitro groups (3) by the gut flora of mammals. This amine (3) as well as 2,6-dinitrotoluene (1) can be hydroxylated by cytochrom P450 at the methyl group to give the substituted benzyl alcohols (6) and (8). Analogous to the metabolic pathway for 2,4-dinitrophenol the benzyl alcohols may be further oxidized to to the substituted benzoic acids (9) or (10). 2-Amino-6-nitrotoluene (3) is either N-acetylated by the liver to (7) and excreted or hydroxylated at the amino group by cytochrome P450. The resulting hydroxylamine (5) may react with biological macromolecules to produce cancer. |
 |