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| Identity |
| 3D Structure |
| Physicochemical data |
| Environmental fate |
| Mammal toxicology |
| Ecotoxicology |
| Metabolism |
| Safety classifications |
| Evaluation |
2-Hydroxyanthraquinone [605-32-3] |
| Theoretical prediction: Although metabolism of 2-hydroxyanthraquinone (1) in mammals has not yet been studied, a metabolic pathway analogous to anthracene may be anticipated. 2-Hydroxyanthraquinone (1) may be oxidized by cytochrome P450 to the correspondent 5,6-epoxide (2) which in turn may either be hydrolyzed by epoxide hydrolase to 1,2-dihydro-9,10-dioxoanthracene-1,2,6-triol (3) or isomerized to phenolic 2,6-dihydroxyanthraquinone (5). Both products may then be conjugated with glucuronic acid or sulfate, (4) and (6), and excreted in urine. Additionally another oxidation by cytochrome P450 to 2,3-dihydroxyanthraquinone (7) may be possible - also followed by conjugation with glucuronic acid or sulfate (8). |
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