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| Identity |
| 3D Structure |
| Physicochemical data |
| Environmental fate |
| Mammal toxicology |
| Ecotoxicology |
| Metabolism |
| Safety classifications |
| Evaluation |
Dichloromethane [75-09-2] |
| Dichloromethane (1) is metabolized in mammals oxidatively with participation of cytochrome P450 to yield the reactive intermediate formyl chloride (2) and subsequently carbon monoxide (3). Formyl chloride (2) may alos react with glutathion (4). This pathway ultimately leads via formic acid (5) to carbon dioxide. Alternatively degradation can be started by direct reaction of dichloromethane (1) with glutathion (4) which is catalyzed by glutathion S-transferases. After spontaneous hydrolysis of the glutathion conjugate (6) formaldehyde (7) is produced which is further oxidized to formic acid (5) and carbon dioxide. The reactive intermediates of the metabolic pathways - as formyl chloride (2) and formaldehyde (7) may be responsible for possible carcinogenic effects of dichloromethane. |
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