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| Identity |
| 3D Structure |
| Physicochemical data |
| Environmental fate |
| Mammal toxicology |
| Ecotoxicology |
| Metabolism |
| Safety classifications |
| Evaluation |
Tetrahydrofuran [109-99-9] |
| This metabolism pathway of tetrahydrofuran (1), which has been shown in bacteria. is probably also the main pathway of biodegradation in mammals. Tetrahydrofuran (1) is hydroxylated by cytochrome P450 to tetrahydrofuran-2-ol (2), which may be either oxidized to butyrolactone (3) or degrade non-enzymatically with ring cleavage to 4-hydroxybutanal (4). 4-Hydroxybutanal (4) is oxidized by aldehyde dehydrogenase to give 4-hydroxybutyric acid (5). Butyrolactone (3) is also hydrolyzed by esterases to 4-hydroxybutyric acid (5). This product can be utilized totally as intermediate in primary metabolism of cells. |
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